Antiulcer activity of dehydroabietic acid derivatives.
نویسندگان
چکیده
منابع مشابه
Antiprotozoal Activity of Triazole Derivatives of Dehydroabietic Acid and Oleanolic Acid.
Tropical parasitic diseases such as Chagas disease and leishmaniasis are considered a major public health problem affecting hundreds of millions of people worldwide. As the drugs currently used to treat these diseases have several disadvantages and side effects, there is an urgent need for new drugs with better selectivity and less toxicity. Structural modifications of naturally occurring and s...
متن کاملSynthesis and biological evaluation of dehydroabietic acid derivatives.
A series of C18-oxygenated derivatives of dehydroabietic acid were synthesized from commercial abietic acid and evaluated for their cytotoxic, antimycotic, and antiviral activities.
متن کاملSynthesis and antiproliferative activity of some novel triazole derivatives from dehydroabietic acid.
Dehydroabietic acid (DHA) is a naturally occurring diterpene with different and relevant biological activities. Previous studies have shown that some DHA derivatives display antiproliferative activity. However, the reported compounds did not include triazole derivatives. Starting from DHA (8,11,13-abietatrien-18-oic acid), and its alcohol dehydroabietinol (8,11,13-abietatrien-18-ol), four alkyl...
متن کاملAnti HHV-1 and HHV-2 activity in vitro of abietic and dehydroabietic acid derivatives
Herpes Simplex Virus types 1 and 2 (HHV-1 and HHV-2) are human neurotropic viruses that infect most commonly the oral and genital area, respectively. Resistant viral isolates can be observed especially in immunocompromised patients. This scenario has triggered the search for new antiherpetic agents, especially those with mechanisms of action different to nucleoside analogs. The antiviral activi...
متن کاملSynthesis and antibacterial evaluation of New N-acylhydrazone derivatives from dehydroabietic acid.
A series of new N-acylhydrazone derivatives were synthesized in good yields through the reactions of dehydroabietic acid hydrazide with a variety of substituted arylaldehydes. The structures of the synthesized compounds were confirmed by IR, 1H- and 13C-NMR, ESI-MS, elemental analysis and single crystal X-ray diffraction. From the crystal structure of compound 4l, the C=N double bonds of these ...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1985
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.33.1472